ENGS 163: Advanced Protein Engineering

Offered

15W: 3B
Ackerman

Textbooks  
Introduction to Protein Structure, Karl Brandon and John Tooze, 2nd edition 1999, ISBN: 0-8153-2305-0 / ISBN13: 978-0-8153-2305-1, Paperback, Garland Science Publishing. Amazon: $87.95

16W: 3B
Ackerman

Prerequisites

ENGS 58, or ENGS 160, or BIOCHEM 101. Equivalent courses accepted with instructor’s permission

This course will build on molecular engineering fundaments introduced in ENGS 58 and equip students to formulate novel engineered molecules by translating methods into practical design proposals. The three components of any protein engineering effort will be surveyed: host strain, library design, and selective pressure. Both gold standard and novel engineering methodologies will be studied, and tradeoffs among different techniques will be examined through detailed case studies. Data presentation and interpretation skills will be developed by examining current literature focused on proteins with practical utility.