Engineering in Medicine Colloquium Series: Ex Vivo Tissue Test Systems: Expanding the Domain of Regenerative Medicine
Karen J.L. Burg, Hunter Endowed Chair and Professor of Bioengineering and Director, Institute for Biological Interfaces of Engineering, Clemson University
Friday, January 11, 2013, 12:30pm
Regenerative medicine is the field at the confluence of science, engineering, and medicine that encompasses the creation of biological substitutes to augment or replace damaged tissues or organs, often using a biomaterial template. The initial promise of tissue engineering was that a damaged tissue might be replaced using a few cells derived from the patient; e.g., new skin might be grown for a burn victim. This early concept of developing tissue for reconstructive purposes has evolved to include the construction of bench-top test tissue systems for therapeutic development, developmental cell biology studies, and disease prevention. Regardless of the end goal, the viability of a tissue engineered product relies on cell-biomaterial interaction and the design of an appropriate 3D microenvironment. This presentation will include an introduction to 3D tissue test system biofabrication, the potential for personalized medicine, and will highlight the interdisciplinary team approach used to attack these massively complex challenges.