John X.J. Zhang
Professor of Engineering
Professor of Engineering1-603-646-8787
Dr. Zhang received his PhD in electrical engineering from Stanford University, and was a research scientist in systems biology at MIT before joining the faculty at UT Austin, where he was tenured in the Department of Biomedical Engineering. His key contribution is in developing miniature medical systems to improve global health, through innovations in bio-inspired nanomaterials, lab-on-chip design, and advanced nanofabrication technologies for probing complex biological networks critical to human development and diseases such as cancer; and multi-scale modeling of the underlining fundamental force, flow, and energy processes. He received the Wallace Coulter Foundation Early Career Award for developing handheld microphotonic imaging scanners and microsystems for early oral cancer detection; NSF CAREER award for the invention of plasmonic scanning probes design for controlled perturbation and imaging at sub-cellular level; and DARPA Young Faculty Award for patterning plasmonic surface on MEMS for biomarker sensing applications. He has published over 120 peer reviewed papers and proceedings, presented over 45 invited seminars worldwide, and filed over 50 US and international patents. His research findings were licensed to two companies: CardioSpectra (acquired by Volcano, Nasdaq: VOLC), and NanoLite Systems for developing successful products designed to diagnose cancer through blood screening, tissue imaging and cell transformations at the point-of-care.
He is an alumnus of NAE Frontiers of Engineering programs, an Associate Editor for Biomedical Microdevices, IEEE/ASME Journal of Microelectromechanical Systems, and has published a textbook for undergraduates titled Molecular Sensors and Nanodevices: Principles, Designs and Applications in Biomedical Engineering.
- BS, Shanghai Jiao-Tong University 1995
- MS, electrical engineering, U Maine at Orono 1998
- PhD, electrical engineering, Stanford University 2004
- Research Scientist, Massachusetts Institute of Technology 2005
Miniature imaging and biosensing systems; bio-inspired nanomaterials; lab-on-chip design; advanced nanofabrication technologies; multi-scale modeling of fundamental force, flow, and energy processes in biological interactions
- ENGS 22: Systems
- K. Hoshino, G. Behave, E. Ng, X.J. Zhang, "Micro Patterned Quantum Dots Excitation and Imaging for Cellular Microarray Screening," Sensors and Actuators A, 216, 301-307, 2014.
- Y. Wang, N. Triesault, D.Y. Gokdel, L. Wang, Y.Y. Huang, and X.J. Zhang, "Magnetic actuated stainless steel scanner for two photon imaging based circulating tumor cell screening," Journal of Micro-Electro-Mechanical Systems, DOI 10.1109, 2014.
- P. Chen, Y.-Y. Huang, K. Hoshino, C.-H. Wu, K.V. Sokolov, X.J. Zhang, "Multiscale immunomagnetic enrichment of circulating tumor cells: from tubes to microchips," Lab on a Chip, 14, 446-458, 2014 (Critical Review)
- K. Hoshino, P. Joshi, G. Bhave, K. Sokolov, and X.J. Zhang, "Use of colloidal quantum dots as a digitally switched swept light source for gold nanoparticle based hyperspectral microscopy," Biomedical Optics Express, Vol. 5, Issue 5, pp. 1610-1615, 2014.
- L. Wang, Y. Wang, and X.J. Zhang, "Embedded metallic focus grating and photonic crystal based lambda/4 nano-slot for subwavelength near-field light confinement," IEEE Journal of Selected Topics in Quantum Electronics, 20,3, 2014.
- Y. Song, Y. Huang, X. Liu, X.J. Zhang, M. Ferrari, L. Qin, "Point-of-care technologies for molecular diagnostics using a drop of blood," Trends in Biotechnology, review for special issue on “Blood”, 32, 3, p132-139, 2014 (invited review).
- S. Bish, M. Sharma, Y. Wang, N. Triesault, J. Reichenberg, X.J. Zhang, J.W. Tunnell, "Handheld diffuse reflection spectral imaging (DRSi) for in-vivo characterization of skin," Biomedical Optics Express, 5, 2, pp. 573-586, 2014.
- C.-H. Wu, Y.-Y. Huang, K. Hoshino, P. Chen, H. Liu, E.P. Frenkel, X.J. Zhang, K.V. Sokolov, "Versatile immunomagnetic nanocarrier platform for capturing cancer cells," ACS Nano, 7(10), 8816-8823, 2013.
- Z.X. Wang, D. Fine, H. Wu, J. Schmulen, Y. Hu, B. Godin, X.J. Zhang, and X. Liu, "Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles," Lab on a Chip, 13, 2879-2882, 2013.
- Y.Y. Huang, K. Hoshino, P. Chen, C. Wu, N. Lane, M. Huebschman, K. Sokolov, J.W. Uhr, E.P. Frenkel and X.J. Zhang, "Immunomagnetic Nanoscreening of Circulating Tumor Cells with a Motion Controlled Microfluidic System," Biomedical Microdevices, 15(4):673-81, 2013.
- T. Sharma, K. Aroom, S. Naik, B. Gill, and X.J. Zhang, "Flexible Thin-Film PVDF-TrFE Based Pressure Sensor for Smart Catheter Applications," Annals of Biomedical Engineering, 41(4): 744-51, 2013.
- Y. Lee, K. Hoshino, A. Alu and X.J. Zhang, "Tunable directive radiation using surface-plasmon diffraction gratings," Optics Express, 21, 3, 2748-2756, 2013.
John X.J. Zhang, Kazunori Hoshino
- National Academy of Engineering, Frontiers of Engineering Program (FOE 2011, FOEE 2012, US-China FOE, 2013)
- DARPA Young Faculty Award, 2010
- NSF CAREER Award, 2009
- British Council Early Career RXP Award, 2008
- Wallace H. Coulter Foundation Early Career Award in Biomedical Engineering, 2006
- Handheld imaging probe (8,767,279)
- Forward-imaging optical coherence tomography (OCT) systems and probes (8,531,676)
- Optically-implemented microsurgery system and approach (8,505,544)
- Uniform transfer of luminescent quantum dots onto a substrate (8,193,010)
- Near-field scanning optical microscope probe having a light emitting diode (7,621,964)
- Mechanically tunable optical-encoded force sensor (7,594,443)
- Co-founder & Scientific Advisor, NanoLite Systems
- American Association for the Advancement of Science (AAAS), Member
- American Physical Society (APS), Member
- American Society for Engineering Education (ASEE), Member
- Biomedical Engineering Society (BMES), Member
- IEEE, Senior Member
- Materials Research Society (MRS), Member
- Optical Society of America (OSA), Member
In Dartmouth Engineer Magazine
Faculty: New Profs
Seminar: Engineering Biology and Medicine at Small Scales: From Cell Manipulation, Molecular Screening to Early Cancer Detection
The Laboratory for Micro-Nano Scale Bio-manipulation, Imaging and Sensing at Thayer School warmly invites applications for 2 Research Associate positions. We are looking for rising scholars with great research potential who are desirous of independent academic or industrial R&D careers. Learn more.
Contact firstname.lastname@example.org to learn about open Ph.D. and postdoctoral positions in his lab.