Skip navigation and go to content
Go to navigation

home
about
Thayer360 Panoramic Virtual Tour

Connect with Thayer School
academics
Foreign Study Programs

Thailand • Hong Kong • Germany
research
Research at Thayer School is advancing innovation in three focus areas:

Engineering at Dartmouth is non-departmental and most projects crosscut traditional engineering disciplines to address critical human needs. Current projects are searchable by focus area and by discipline.
people
Information for ...

Karl Griswold

Assistant Professor of Engineering

1-603-646-2127
karl.e.griswold@dartmouth.edu

Education

B.S., Chemistry, Southwest Texas State University 1995
Ph.D., Chemistry, University of Texas at Austin 2005

Research Interests

Protein engineering; directed evolution; biotherapeutics; applied biocatalysis; high throughput screening

Current Research Projects

Teaching

ENGS 158: Chemical Kinetics and Reactors
ENGS 162: Methods in Biotechnology
ENGS 163: Protein Engineering

Selected Publications

Zheng, W., Griswold, K.E., Bailey-Kellogg, C. Protein fragment swapping: A method for asymmetric, selective site-directed recombination. Proceedings of the 13th Annual International Conference on Research in Computational Molecular Biology (2009) pp. 321-338.
Griswold, K.E., Aiyappan, N.S., Iverson, B.L., Georgiou, G. The Evolution of Catalytic Efficiency and Substrate Promiscuity in Human Theta Class 1-1 Glutathione Transferase. Journal of Molecular Biology (2006), 364(3), 400-10.
Griswold, K.E., Kawarasaki, Y., Ghoneim, N., Benkovic, S.J., Iverson, B.L., Georgiou, G. Evolution of highly active enzymes by homology-independent recombination. Proceedings of the National Academy of Sciences, USA (2005), 102(29), 10082-7
Levy, M., Griswold, K.E., Ellington, A.D. Direct selection of trans-acting ligase ribozymes by in-vitro compartmentalization. RNA (2005), 11(10):1555-62
Griswold, K.E. pH sensing agar plate assays for esterolytic enzyme activity. Methods in Molecular Biology (Totowa, NJ, United States) (2003), 230, 203-11
Griswold, K.E., Mahmood, N.A., Iverson, B.L., Georgiou, G. Effects of codon usage versus putative 5'-mRNA structure on the expression of Fusarium solani cutinase in the Escherichia coli cytoplasm. Protein Expression and Purification (2003), 27(1), 134-42

Awards

Wallace H. Coulter Foundation Early Career Translational Research Award in Biomedical Engineering (2008)
NIH Biotechnology Training Grant (2000-2003)
Royston M. Roberts - Regents Fellowship, University of Texas (1999)
DOW Chemical Foundation Scholar, Texas State University (1991-1995)
Presidential Upper Division Scholar, Texas State University (1994-1995)
ACS Polymer Education Committee Award for Organic Chemistry (1993)

Selected Patents

Griswold, Karl E. Primary alkanolamides, their preparation and their uses. PCT Int. Appl. (2000), 23 pp. CODEN: PIXXD2 WO 2000066543 A1 20001109 CAN 133:335966 AN 2000:790464 CAPLUS

Professional Activities

Member, AIChE
Member, ACS
Member, SIM
Member, ASEE

News

Students selected for SURF biomed program
Fosters.com
June 14, 2011
Hitchcock Foundation funds lung-disease project
DMS
April 27, 2011
NCI Awards $12.8 Million to Dartmouth Center of Cancer Nanotechnology Excellence
Dartmouth Now
September 17, 2010
Engineering Students Awarded Thayer School Fellowships
April 2, 2010
Dartmouth Engineer earns top ranking from CFF
April 4, 2008

In Dartmouth Engineer Magazine

The New Guard: Thayer's eight new tenure-track assistant professors will influence the next few generations of students.
Winter 2011
Kudos
Summer 2010
Engineering in Medicine: Behind every great medical advance, there's a great engineer
Summer 2009
Faculty: Thayer Gains Five New Professors
Winter 2008

Video

Seminar: Molecular Engineering of WMD (Weapons of Microbial Destruction)

Therapeutic Protein Research