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VideoMargie Ackerman
Assistant Professor of Engineering
margaret.e.ackerman@dartmouth.edu
Education
- B.S., M.S., Chemistry, Biochemistry, Brandeis University 2003
- Ph.D., Biology, Massachusetts Institute of Technology 2010
Research Interests
Protein engineering; biotherapeutics; vaccine technology; engineering immune responses
Current Research Projects
Teaching
- ENGS 25: Introduction to Thermodynamics
Selected Publications
- Ackerman M.E., Lai J.I., Pastan I., Wittrup K.D., Exploiting bias in a non-immune human antibody library to predict antigenicity. Protein Eng Des Sel., (in press)
- McAndrew E.G., Dugast A.S., Alter G., Ackerman M.E., Determining the phagocytic activity of clinical antibody samples. J Vis Exp., (in press)
- Ackerman M.E., Dugast A.S., Alter, G.A. 2012. Emerging concepts on the role of innate immunity in the prevention and control of HIV infection. Ann Rev Med. (in press)
- Dugast A.S., Tonelli A., Berger C.T., Ackerman M.E., Sciaranghella G., Liu Q., Sips M., Toth I., Piechocka-Trocha A., Ghebremichael M., Alter G. 2011 May 11. Decreased Fc receptor expression on innate immune cells is associated with impaired antibody-mediated cellular phagocytic activity in chronically HIV-1 infected individuals.Virology. (Epub ahead of print)
- Levary D.A., Parthasarathy R., Boder E.T., Ackerman M.E. 2011 Apr. Protein-protein fusion catalyzed by sortase a. PLoS One. 6;6(4):e18342.
- Ackerman M.E., Moldt B., Wyatt R.T., Dugast A.S., McAndrew E., Tsoukas S., Jost S., Berger C.T., Sciaranghella G., Liu Q., Irvine D.J., Burton D.R., Alter G. 2010. A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples. J Immunol Methods. [Epub ahead of print] PMID: 21192942.
- Hackel B.J., Ackerman M.E., Howland S.W., Wittrup K.D. 2010. Stability and CDR composition biases enrich binder functionality landscapes. J Mol Biol. 6;401(1):84-96.
- Orcutt, K.D., Ackerman, M.E., Cieslewicz, M., Quiroz, E., Slusarczyk, A.L., Frangioni, J.V., and Wittrup, K.D. 2009. A modular IgG-scFv bispecific antibody topology. Protein Eng Des Sel 23:221-228.
- Ackerman, M., Levary, D., Tobon, G., Hackel, B., Orcutt, K.D., and Wittrup, K.D. 2009. Highly avid magnetic bead capture: an efficient selection method for de novo protein engineering utilizing yeast surface display. Biotechnol Prog 25:774-783.
- Ackerman, M.E., Pawlowski, D., and Wittrup, K.D. 2008. Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids. Mol Cancer Ther 7:2233-2240.
- Ackerman, M.E., Chalouni, C., Schmidt, M.M., Raman, V.V., Ritter, G., Old, L.J., Mellman, I., and Wittrup, K.D. 2008. A33 antigen displays persistent surface expression. Cancer Immunol Immunother 57:1017-1027.
News
Thayer prof. works on HIV vaccine
The Dartmouth
January 6, 2012Ragon and Dartmouth collaborate to tailor new vaccine approach against HIV
December 20, 2011